In the search for new PDK1/Akt inhibitors as a promising treatment for GBM, the oxindole nucleus present in different PI3K/Akt pathway inhibitors [46,47,48], a small family of 2-oxindole derivatives of general formula 5 (Chart 2, Figure 1) were synthesized and evaluated in vitro [49]. The gene discussed is PDK1; the disease is glioblastoma.