SERS-based simultaneous detection of squamous cell carcinoma antigen (SCCA) and osteopontin (OPN) in serumDetection limit: 8.628 pg/mL for SCCA and 4.388 pg/mL for OPNSERS intensities at 1593 cm−1 (SCCA) and 1334 cm−1 (OPN) increased in serum from cervical cancer and precancer patients compared to healthy subjectsGood agreement between SCCA and OPN levels measured by SERS and ELISA in serum samples. Here, SPP1 is linked to cervical cancer.