In different cancers, cellular turnover of c-MYC has been regulated by different USPs [21,22,23,24,25,26,27,28], with notable examples including the maintenance of c-MYC turnover by direct physical interactions of USP28 in colon carcinoma [22], USP36 in breast carcinoma [23] and USP37 in lung cancer [27]. Here, USP28 is linked to lung cancer.