IL6 and colitis: In addition, Kovacs-Nolan et al. [129] discovered that the soybean protein hydrolysate had a “Val-Pro-Tyr” peptide sequence which showed an anti-inflammatory effect by reduced MPO activity, decreased gene expression of the pro-inflammatory cytokines TNF-α, IL-6, IL-1β, IFN-γ, and IL-17 in the colon, improved colon histology, and reduced DSS-induced colitis symptoms and weight loss in vivo in a mouse model of Dextran sodium sulfate DSS-induced colitis.