The sarcopenia, when no specific etiologic cause can be identified, is progressive and associated with the aging impact: a reduction in motor neurons; alterations in skeletal muscle tissue, including mitochondrial dysfunction; changes in the hormonal milieu, including a decrease in IGF-1; and an increase in proinflammatory cytokines, such as TNF-α and IL-6. The gene discussed is IL6; the disease is sarcopenia.