A number of factors, however, have shown an influence on the variability of diagnostic alternatives in the management of newborns at risk, including overdiagnosis of chorioamnionitis (frequently based solely on intrapartum maternal fever), intrapartum antimicrobial therapy that contributes to negative blood cultures, the low specificity and negative predictive value of infection biomarkers used in neonates (IL-6, CRP, procalcitonin), or the lack of specificity of clinical manifestation of sepsis, particularly in preterm newborns [2,6,8]. This evidence concerns the gene IL6 and Sepsis.