Nucleotide-binding oligomerisation domain-like receptor protein NLRP3 and NLRP6, which belong to the family of inflammasomes, balance the immune response with the expression of interleukin IL-1b and IL-18, serving as regulators of normal microbiota and ameliorating NAFLD, whereas dysbiosis has been associated with a decrease in those inflammasomes and NAFLD occurrence in animal models [47,48,49]. Here, IL18 is linked to metabolic dysfunction-associated steatotic liver disease.