Having observed dysregulation in the levels of IFNλs and IFNγ in BAL cells from COVID-19 patients, and given that TLR2 [33], TLR3 [34], TLR4 [35] and TLR7/TLR8 [36] are involved in anti-SARS-CoV-2 response and related to IFN production after viral and/or bacterial infections [37], we investigated whether these TLRs were differently expressed in COVID-19 patients. This evidence concerns the gene TLR4 and bacterial infectious disease.