In this study, in line with the weaker Th1 response of WSX-1−/−-DC recipients in the adoptive transfer experiments, IL-10 expression and secretion in WSX-1−/− splenic DCs were significantly higher than in WT mice, suggesting that IL-27/IL-27R may mediate protective Th1 immunity by suppressing the IL-10 production of DCs in C. muridarum respiratory infection. Here, IL27RA is linked to respiratory tract infectious disorder.