Combined with the consistency between the higher IL-10 level and weaker Th1 response in the WSX-1−/− mice, we tend to draw the conclusion that, though impacting the mature phenotype, IL-27/IL-27R primarily regulates the Th1 response through modulating the DC cytokines profile in chlamydial infection. This evidence concerns the gene IL27 and chlamydia trachomatis infectious disease.