Interestingly, mRNA BDNF ratio pre/post therapy was negatively correlated with the severity of insomnia symptoms (AIS score) at the baseline (r = −0.409, p = 0.042; Table 6; Figure 5a), poor sleep quality (r = −0.441, p = 0.027; Table 6; Figure 5b). The gene discussed is BDNF; the disease is insomnia.