NFE2L2 and breast cancer: In FF of BC patients, we observed a decreased level of Nrf2; the failure to activate the complex downstream antioxidant enzymes, such as NAD(P)H dehydrogenase quinine 1 (NQO1) and cytoprotective protein SOD, might have determined an increase of CXCL10, a 10 kDa proinflammatory chemokine, that is also a modulator of physiological ovarian function [59].