Analysis of secondary variables revealed no significant changes in CSF phosphorylated tau, CSF total tau (t-tau), CSF Aβ1–42, MMSE, Alzheimer’s Disease Assessment Scale-cognitive (ADAS-Cog), controlled oral word association test (COWAT), category fluency test (CFT), one-card learning memory task (OCL), identification reaction time task (IDN), and detection reaction time task (DET) [44]. This evidence concerns the gene MAPT and Alzheimer disease.