Interestingly, mutations, and/or variants, in the genes encoding four of the other elongator complex proteins are associated with neurological and cognitive impairment disorders including ALS (with the C9orf72 ALS associated gene variant giving rise to reduced ELP3 expression) [17], intellectual disability (associated with a mutation in the ELP2 gene), and Rolandic epilepsy or ASD (associated with a mutation or microdeletion, respectively, in the ELP4 gene) [13,18]. Here, ELP3 is linked to amyotrophic lateral sclerosis.