Meloche et al. in two landmark papers [39,40] worked on miR-223 function that reversed experimental pulmonary arterial hypertension and, in the PAH, coupled CAD mating phenotypes with a well-defined role in the increased expression of miR-223/DNA/Poly [ADP-ribose] polymerase 1/miR-204 in causing the damage. Here, PARP1 is linked to pulmonary arterial hypertension.