REN and hypertensive disorder: In addition to nutrient-sensing signals, several molecular mechanisms involved in hypertension programming have been proposed based on prior research, covering oxidative stress [65], nitric oxide (NO) deficiency [103], aberrant renin-angiotensin system (RAS) [104], epigenetic regulation [105], increased sympathetic nerve activity [106], sex differences [107], gut microbiota dysbiosis [108], and impaired sodium transport [109].