PIK3CA and neoplasm: Table S3 summarizes the mutation profile of metabolic subtype-1 and subtype-2 samples. The mean Tumor Mutation Burden (TMB) per Mb of metabolic subtype-2 (32.38) was higher compared to metabolic subtype-1 (25.78) samples. The five most frequently mutated genes in metabolic subtype-1 samples were PTEN (90%), AR1D1A (56%), PIK3CA (55%), TTN (40%), and PIK3R1 (39%) (Figure 6). On the other hand, TP53 (70%), PIK3CA (44%), TTN (39%), PTEN (32%), and PPP2R1A (30%) were the top five frequently mutated genes in metabolic subtype-2 samples (Figure 6). TTN is frequently mutated in both subtypes.