During tumor inhibition, multiple protein kinases and signaling pathways are modulated via apigenin, such as mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), PI3K/Akt, janus kinase/signal transducers and activators of transcription (JAK/STAT), NF-κB, and Wnt/β-catenin [11]. Here, AKT1 is linked to neoplasm.