The novelty of our research is to examine the expected role of SeNPs and BV in ameliorating the deleterious effects that result as long-term complications of diabetes through evaluating their biochemical effects on serum cardiac and renal markers, and histopathological effects on cardiac and kidney tissues; we also undertook molecular evaluation of their effects on miR-21 and miR-328, the miRNAs closely related to cardiac and renal fibrosis, with a molecular evaluation of their regulated genes (TGFβ1, JNKs, STATs, NFκβ and SMADs) in cardiac and renal tissues. The gene discussed is TGFB1; the disease is diabetes mellitus.