This idea motivates us to evaluate the role of SeNPs and/or BV as hypoglycemic agents in the reduction of cardiac and renal fibrosis produced as a long-term diabetic complication, through examining their effects on the expression levels of miR-21 and miR-328, the genes involved in the regulation of cardiac and renal fibrosis, as well as by examining their effects on the genes of JAK/STAT, TGF-β/SMAD and TGF-β/NF-kβ signaling pathways, the main pathways involved in cardiac and renal fibrosis. Here, NFKB1 is linked to renal fibrosis.