Several molecular proteins and signaling pathways have been implicated as an important marker for the development of DCM and DN, including Micro RNAs (miRNA), Janus kinase (JAK) signal transducer and activator of transcription factor proteins (STATs) (JAK/STAT), transforming growth factor β1 (TGF-β1)/SMAD and TGF-β/NF-kβ pathways [20,21,22,23,24,25]. The gene discussed is TGFB1; the disease is familial dilated cardiomyopathy.