HKs (HK1 and HK2), PFK1 and PFK2, G6PD, pyruvate kinase, phosphoglycerate dehydrogenase (PHGDH), lactate dehydrogenase, phosphoglycerate kinase 1 (PGK1), enolase (ENO), isocitrate dehydrogenase (IDH), and glucose transferase (GLUT) serve as ideal pharmacological targets to treat cancer. The gene discussed is PGK1; the disease is cancer.