HIF1A and cancer: The crude Astragalus saponins extracted from Astragalus membranaceus (Fabaceae) exhibited anti-cancer effects against colon and gastric cancer at 80 and 50 μg/mL, respectively, via inhibiting angiogenesis-inducing signaling pathways, including VEGF, bFGF, HIF-1α, and PI3K/mTOR/Akt [225,226].