VEGFA and ovarian cancer: Oldhamianoside II (5, 10, and 20 mg/kg), a bidesmosidic oleanolic acid derivative saponin of Gypsophila oldhamiana roots (Caryophyllaceae), markedly revealed anti-cancer activities against sarcoma and ovarian cancers via blocking the multi-targets of angiogenesis pathways, including VEGF and VEGFR2, COX-2, bFGF, and pro-inflammatory cytokines, such as TNF-α and IL-6 [199,200].