Overall median PSA density was 0.2 (IQR: 0.1–0.3, 0.1 [IQR: 0.1–0.2] vs. 0.2 [IQR: 0.1–0.3] vs. 0.3 [IQR: 0.1–0.5] in low-risk vs. intermediate-risk vs. high-risk PCa patients, respectively, p-value < 0.001). Here, KLK3 is linked to posterior cortical atrophy.