Regarding prebiotics, their use, in combination with probiotics, is recommended, as suggested by a recent review that underlines the importance of this combined approach that showed a significant reduction in the levels of hepatic steatosis, alanine aminotransferase (ALT), AST, HDL, LDL, triglyceride and cholesterol levels in 782 MAFLD patients compared to healthy controls [96]. The gene discussed is GPT; the disease is fatty liver disease.