GAPDH and metabolic syndrome: Importantly, aMt leak superoxide or mitochondria ROS (mtROS), which induce deoxyribonucleic acid (DNA) strand breaks and activate nuclear poly (ADP-ribose) polymerase, resulting in decreased glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and subsequently increase the previous causes for increased oxidative stress in the MetS reloaded (pathways1-6) [11,100,111,112,113].