In obesity, the adipose tissue is an active endocrine and paracrine organ that releases several bioactive mediators including adipokines, cytokines/chemokines and toxic saturated free fatty acids (FFA) that influence not only body weight homeostasis but also inflammation, coagulation, fibrinolysis, as well as insulin and leptin resistance [190]. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.