In the present study, we analyzed the expression profile of REST in CIN 1, CIN 2/3, SCC, and ADC, as well as the transcriptional effect of the reduced expression of REST on the expression of CgA, CHRNβ2, BDNF, CHRM4, CRF, CDH1, CREB, GluR1, Xbp1, Kif17, and RASSf1A genes in HeLa cells. The gene discussed is CREB1; the disease is AIDS dementia complex.