In the present study, we analyzed the expression profile of REST in CIN 1, CIN 2/3, SCC, and ADC, as well as the transcriptional effect of the reduced expression of REST on the expression of CgA, CHRNβ2, BDNF, CHRM4, CRF, CDH1, CREB, GluR1, Xbp1, Kif17, and RASSf1A genes in HeLa cells. Here, XBP1 is linked to AIDS dementia complex.