We believe the reason for this increase in menstrual duration and menstrual bleeding in the MDD group may be due to the effect of increased ACTH in depression and, therefore, the effect of cortisone, while the stress situation in depression may have increased due to an increase in blood bradykinin and prostaglandin levels, causing enlargement of the pelvic blood vessels and an increase in blood flow [14]. This evidence concerns the gene POMC and major depressive disorder.