Because the rise in CA125 is unspecific, it cannot serve as a biomarker for endometriosis alone, but its role in scientific research is well documented; however, the cut-off value of CA125 differs from 15 U/mL [17], through 20 U/mL to 85 U/mL according to several multi-center studies and meta-analyses [22,23,24]. This evidence concerns the gene MUC16 and endometriosis.