In a review by Rowlands et al. [55], GLP-1 Ras are reported to improve kidney function by an increment in renal blood flow and a secondary amelioration of eGFR, with the prevention of plasma creatinine rise, which is similar to our study results, which show that, in the patients with T2DM that were treated with GLP-1 RAs, their urea levels improved at V6M as compared to V0M. Here, GLP1R is linked to type 2 diabetes mellitus.