The 6-month characteristics of safety included a few ARs, such as hypoglycemia (one patient in the SGLT-2i and GLP-1 RA groups, respectively), with five cases of nausea in the GLP-1 RA group, two cases of urinary tract infections in the SGLT-2i group, and those without palpitations, alongside the biologic parameters of safety, which were, respectively, creatinine, eGFR, UACR, urea, GOT, and GPT, as seen in Table 4. This evidence concerns the gene GLP1R and urinary tract infection.