GLP1R and type 2 diabetes mellitus: To sum up, SGLT-2is and GLP-1 RAs, along with metformin, are safe for renal and hepatic profiles, when administered to patients with T2DM who receive the standard-of-care treatment with the maximum tolerated doses of BP-lowering and lipid-lowering medication, alongside a few adverse reactions that are specific to each of the classes.