Finally, the LC3B-II/I ratio (LC3B-II is an indicator of the number of autophagosomes, while LC3B is the main isoform of LC3) and ATG5 protein levels were increased as a result of apatinib treatment of SH-SY5Y and BE(2)-M17 NB cells [39,48]. This evidence concerns the gene MAP1LC3B and neuroblastoma.