HDAC8 and neuroblastoma: Further, the depletion of miR-144-3p (using anti-miR-144-3p) reduced the suppressive effects of siRNA-mediated NORAD depletion on NB cell proliferation, migration, metastasis, and DOX resistance; hence the NORAD exerted its oncogenic effects through the negative regulation of miR-144-3p. Furthermore, histone deacetylase 8 (HDAC8) was shown to be a target of miR-144-3p in NB since the protein levels of HDAC8 were increased or decreased as a result of anti-miR-144-3p treatment or miR-144-3p accumulation, respectively.