TERT and neuroblastoma: Additionally, high-risk NB may encompass two other subgroups, including alternating length of telomeres (ALT) (approximately 25%) and 23–31% of cases displaying telomere reverse transcriptase (TERT) gene rearrangements (e.g., rearrangement of 5p15.33, leading to strong enhancer insertion into TERT coding sequences) [9,15,16].