FOXO1 and neoplasm: Furthermore, the role of MEG3 was reviewed, and it was shown that this nucleus-based lncRNA may be acting as a suppressor of autophagic processes through the axis of FOXO1, but not mTOR and this suppression affected genes such as Beclin 1 and hence may be affecting nucleation and phagophore formation, while the downregulation of MEG3 led to enhanced proliferation and migration, hence MEG3 may be limiting tumour growth, proliferation and migration steps (steps 1–2 and 4) [36].