MTOR and neuroblastoma: Finally, the downregulation of MEG3 (by using a MEG3 silencer) led to NB malignant characteristics, including enhanced proliferation, migration, and invasion established using transwell assays in an mTOR-dependent fashion, while the silencing of MEG3 increased autophagy markers, including ATG16, Beclin 1 and ATG3, collectively bringing into light the role of MEG3 as a negative regulator of autophagy and metastasis in NB [36] (Figure 5).