FMR1 and fragile X-associated tremor/ataxia syndrome: In recent studies, however, unique disorders related to the premutation in the FMR1 gene have been reported, including the Fragile X-associated primary ovarian insufficiency (FXPOI) and Fragile X-associated tremor/ataxia syndrome (FXTAS), with abnormal gait, memory, and executive dysfunction [6,10,11,12,18,25,26].