Resistant hypertension (RH) is defined as BP levels over the target limits despite the simultaneous use of three anti-hypertensive drugs from different pharmacological classes, ideally including a long-acting calcium channel blocker, a renin-angiotensin system inhibitor (RAS-i), and a diuretic administered at maximum doses or maximum tolerated doses [12]. This evidence concerns the gene REN and Hypertension resistant to conventional therapy.