PTGS1 and hemorrhage: Although the hexane and dichloromethane extract exhibited a noteworthy and potential IC50 value of 5.87 and 8.08 μg/mL against COX-1, it is not of paramount importance as the extracts inhibiting COX-1 are likely to tamper negatively with the functioning of human essential organs and further result in hemorrhage, kidney failure, and or severe side effects on the gastrointestinal area [66].