SLC5A2 and hydrops fetalis: Sodium–glucose co-transporter-2 inhibitors (SGLT-2) inhibitors, a novel drug class, inhibit the SGLT-2 receptors predominantly expressed in the proximal tubule of the nephron; thus, they induce glycosuria and natriuresis and have been shown to reduce the combined endpoint of all-cause mortality and HF rehospitalization in chronic HF patients irrespective of the LVEF [32,33,34,35,36].