The current author postulates that the aforementioned progressive loss of Nav1.1 activity from intrafusal proprioceptive terminals due to irreversible loss of Piezo2 input could initiate the impairment of Nav1.6 Na+ channels in the SOD1G93A mouse model for ALS, as shown by Seki et al. [54]. Here, SCN8A is linked to amyotrophic lateral sclerosis.