Accordingly, it was suggested that Piezo2 is the principal one and the non-contact terminal microinjury of it could lead to the progressive non-contact dying-back injury mechanism of ALS and eventually to incompatibility with life sustainment when environmental risk factors or genetic predisposition, such as SOD1 mutation, are associated with it [4,5]. This evidence concerns the gene PIEZO2 and amyotrophic lateral sclerosis.