IGF1R and Alzheimer disease: Tg2576 mice crossed with nIGF1R−/− (Tg2576 X nIGF1R−/−) showed prolonged survival and improved AD pathology and cognitive dysfunction, similar to those crossed with IGF1R heterozygous (IGF1R+/−) mice (Tg2576 X IGF1R+/−) [134,135,136,137].