Raisch et al. demonstrated that LRP6 did not affect tumorigenesis in APCMin/+ mice, and they also showed that LRP6 knockdown did not affect the colony formation activity and cell growth in CRC cells with APC or CTNNB1 mutations, suggesting that LRP6 is dispensable for tumorigenesis induced by an aberrant Wnt/β-catenin pathway [29]. Here, APC is linked to colorectal carcinoma.