Furthermore, although other studies have obtained similar findings indicating that CPAP therapy may reduce the levels of Aβ42 and T-Tau in patients with OSA combined with mild cognitive impairment [40], the present study enrolled only patients with OSA who had no cognitive problems and, therefore, was able to provide evidence that CPAP interventions can benefit patients with OSA alongside typical cognitive function and provide early prevention of cognitive impairment. Here, MAPT is linked to Cognitive impairment.