In addition, the correlations between the AGTR1 gene and different types of immune checkpoint genes in GC samples were calculated, and it was found that the AGTR1 gene is associated with immune checkpoint genes such as TGFB1, VEGFA, TNF, 1L4, HLA-A, PDCD1, CD80, HMGB1, and ENTPD1 (Figure 4F). This evidence concerns the gene HMGB1 and gastric cancer.