PCSK9 and cirrhosis of liver: Recently, a study carried out on alcoholic cirrhotic patients [114] has shown that high serum PCSK9 was reduced in patients with liver cirrhosis in comparison to non-cirrhotic patients; that plasma PCSK9 was not correlated with Child–Pugh score, MELD score, bilirubin or aminotransferases, but it was associated with low levels of certain cholesteryl ester and sphingomyelin species.