Yan et al. [17] measured plasma NRG4 levels in T2DM patients by ELISA and found that the level of NRG4 was negatively correlated with most of the metabolic syndrome analysis (MetS) indicators, and the decrease of plasma NRG4 level may be related to oxidative stress, inflammation and dyslipidemia, which may be related to the occurrence of MetS in T2DM patients. This evidence concerns the gene NRG4 and type 2 diabetes mellitus.