NRG4 and diabetes mellitus: Multivariate logistic regression analysis was performed on all the factors affecting the occurrence of DKD in patients, and the results showed that HCY/NRG4 (HR: 1.870, CI: 1.496–2.573, p < 0.001); course of DM (HR: 1.015, CI: 1.004–1.029, p = 0.012) was an independent factor influencing the occurrence of DKD in patients (Table 2).