In the present experiment, we found that MEF2B, CCDC187, PSD2, RGS16, PLXDC1, ARV1, HELB, ASIC3, PLCH2, IGF2BP3, CLHC1, DNHD1, SACS, H1-4, ANKRD36, and ZNF117 all had poor and statistically significant prognosis in COAD tissues. This evidence concerns the gene H1-4 and colon adenocarcinoma.