Our results suggest that MEF2B, CCDC187, PSD2, RGS16, PLXDC1, ARV1, HELB, ASIC3, PLCH2, IGF2BP3, CLHC1, DNHD1, SACS, H1-4, ANKRD36, and ZNF117 can be used as predictors of overall survival prognosis in patients with COAD. Here, HELB is linked to colon adenocarcinoma.