H1-4 and colorectal cancer: High-throughput sequencing and bioinformatics analysis showed that MEF2B, CCDC187, PSD2, RGS16, PLXDC1, ARV1, HELB, ASIC3, PLCH2, IGF2BP3, CLHC1, DNHD1, SACS, H1-4, ANKRD36, and ZNF117 could be the targets of action of rotundine to inhibit colorectal cancer, which may be for further provide new biomarkers for the diagnosis and treatment of colorectal cancer.