Sawayama, H. et al. found that, in patients with rectal cancer, low preoperative TRF level was closely related to short postoperative OS and cancer-specific survival (CSS), and preoperative low TRF was associated with low hemoglobin, low albumin, and high white blood cell counts, as well as high C-reactive protein of pre-operation [26]. The gene discussed is CRP; the disease is rectal cancer.