Different molecular phenotypes play different roles in tissue radio-sensitivity, and the overexpression of peptidyl-arginine deiminase 4 (PAD4) promoted radio-resistance, survival, migration, and invasion of NPC cells [15]; the overexpression of the long non-coding RNAs, such as plasmacytoma variant translocation 1 (PVT1) and miR-483-5p, reduce NPC radio-sensitivity by decreasing radiation-induced apoptosis and DNA damage [16]. Here, PADI4 is linked to nasopharyngeal carcinoma.