Combining the results of the above studies, we explored that with the stimulation of some inflammatory factors and other pathogenic factors, pendrin may enhance the infiltration of NEU in the nasal cavity and paranasal sinus mucosa, and then promote the secretion and expression of mucin in epithelial and glandular tissues through EGFR signal, which led to the occurrence and development of CRS. The gene discussed is MUC5AC; the disease is congenital rubella syndrome.