Then, multivariate ROC showed that programmed cell death risk score (AUC:0.705) was more effective than PD-1 (AUC:0.453), PD-L1(AUC:0.497), CTLA4(AUC:0.417), TMB(AUC:0.506), LAG3(AUC:0.485), TIM-3(AUC:0.419), and MSI(AUC:0.475) in predicting the prognosis of lung adenocarcinoma (Figure 8F). The gene discussed is CTLA4; the disease is lung adenocarcinoma.