In this study, we included pancreatic sufficiency status as a covariate to adjust for difference in pancreatic insufficiency prevalence in calculated quartiles, but we do not provide separate references for pancreatic sufficient and insufficient patients, as outcomes related to glucose tolerance and insulin secretion are likely to occur independently from pancreatic insufficiency when considering the endocrine pancreatic function. The gene discussed is INS; the disease is exocrine pancreatic insufficiency.