GHRL and obesity due to melanocortin 4 receptor deficiency: Subsequent research has uncovered an association of various other GHRL variants with obesity: rs4684677 in a general-population cohort of European origin [112]; rs35682 and rs35683 in a white American population [113], and rs696217 in a Japanese population [114]; in addition, rs35681 correlates with the development of obesity in polycystic ovary syndrome [115].