The explorative analyses of intrinsic mechanisms, in terms of cancer hallmarks, suggested that the NES values of the CLR-high group were greatly higher in angiogenesis (p < 2.2 × 10−16, autophagy (p < 2.2 × 10−16), cell cycle (p = 5.3 × 10−13), EMT (p = 8.3 × 10−14), Hippo (p < 2.2 × 10−16), JAK-STAT (p = 0.0085), MAPK (p < 2.2 × 10−16), PI3K-AKT (p < 2.2 × 10−16), mTOR (p = 4.4 × 10−8), and TGF-β signaling pathways (p < 2.2 × 10−16). The gene discussed is DCLK3; the disease is cancer.