It is surprising that, in HCC patients at the BCLC early stage, geriatric status, gender (male), diabetes, hypertension, albumin < 3.0 (g/dl), prolonged PT > 3.0 (sec), bilirubin > 3.0 (mg/dl), creatinine > 2.0 (mg/dL), WBC ≤ 4.0 (×1000/μL), SII > 610 × 1000/μL, AFP > 10 (ng/mL), tumor size > 3 (cm), and the initial treatment mode (RFA vs. surgery) were not significantly associated with HCC recurrence. The gene discussed is AFP; the disease is hepatocellular carcinoma.