PIDs associated with increased susceptibility to invasive fungal disease can be classified as phagocytic defects (Chronic granulomatous disease (CGD), Leukocyte adhesion deficiencies (LAD) and congenital neutropenia), cellular and combined immunodeficiencies (e.g., SCID, CIDs) and PIDs with defective Th17 immunity (AD-HIES, CARD9 deficiency). Here, CARD9 is linked to Alzheimer disease.