IGHE and asthma: The criteria proposed for SAFS diagnosis include the occurrence of severe asthma (which is symptomatic and uncontrolled asthma despite the treatment with high doses of inhaled corticosteroids plus a second controller and/or systemic corticosteroids) [49], evidence of IgE sensitization to molds (SPT or fungal-specific IgE), mainly to thermotolerant filamentous fungi (Aspergillus spp.