Immune checkpoint inhibitors (ICIs) targeting programmed cell death-1 (PD-1), programmed cell death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) have revolutionized the prognosis of advanced renal cell carcinoma (RCC) [1,2,3]. The gene discussed is CTLA4; the disease is hereditary clear cell renal cell carcinoma.