Very recently published experimental work using vascular smooth muscle cells (VSMCs), including VSMCs from donors with diabetes, showed that the disruption of the myogenic vasoconstriction in retinal arterioles in diabetes was associated with a downregulation of transient receptor potential vanilloid subtype 2 (TRPV2) cation channels and loss of vascular smooth muscle cells stretch-activated cation currents [25]. Here, TRPV2 is linked to diabetes mellitus.